Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes

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Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes

Epidemiological studies suggest that a father's diet can influence offspring health. A proposed mechanism for paternal transmission of environmental information is via the sperm epigenome. The epigenome includes heritable information such as DNA methylation. We hypothesize that the dietary supply of methyl donors will alter epigenetic reprogramming in sperm. Here we feed male mice either a fola...

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The paternal sperm epigenome: implications for development and disease

Despite the father transmitting half the heritable information to the embryo the focus on preconception health has largely been on the mother. New studies highlight the role of the father in disease transmission via non-genetic inheritance, through epigenetic mechanisms. Epigenetic mechanisms include, DNA methylation, post-translational modifications of histones and noncoding RNAs. Paternal eff...

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ژورنال

عنوان ژورنال: Nature Communications

سال: 2013

ISSN: 2041-1723

DOI: 10.1038/ncomms3889